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KMID : 0350519960490030927
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Journal of Catholic Medical College
1996 Volume.49 No. 3 p.927 ~ p.934
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The Ileal Permeability Changes on Temporary Occlusion of Superior Mesentric Artery in Rats
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Abstract
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Ischemia is a common clinical event with potentially serious consequence. The small intestine is one of the most sensitive tissue to ischemia-reperfusion injury. Reperfusion of intestine is often associated with increases in vascular and mucosal permeability and mucosal ulceration. Several studies have shown that relatively little injury to the intestinal mucosa occurs during the ischemic period, the majority occuring upon reperfusion. The exact mechanisms leading to mucosal injury, due to mesenteric ischemia-reperfusion, have not been fully elucidated, yet there is an increasing body of
evidence to suggest a role for xanthine oxidase derived oxygen metabolites.
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